FEATURED CASE STUDIES

FEATURED CASE STUDIES

Lead Product Designer • 2019-2021

The National Institutes of Health: Biomedical Translational Research Information System (BTRIS)

BTRIS is the NIH's centralized clinical research data system—managing over 600,000 research subjects across 10,000+ protocols. The legacy platform was difficult to use, expensive to maintain, and inaccessible to external researchers. I led the UX strategy to modernize the interface, decouple reporting from IBM Cognos, and reduce onboarding friction.

BTRIS Reports

On-Demand, Customizable Reports to Accelerate Research and Clinical Insights

BTRIS reports provide researchers and clinicians with on-demand access to comprehensive, de-identified or identified patient data, tailored to their study protocols. These customizable reports streamline data analysis, support evidence-based decisions, and enhance research efficiency—all within a secure, compliant framework.

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Ingesting raw data.

Quickly select protocols and custom subject Lists

Stakeholders can select from their curated list of protocols and subjects both identified or de-identified.

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P

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Share with other researchers

BTRIS makes it easy for researchers to collaborate by allowing secure sharing of subject lists and reports with authorized team members. Investigators can share data with colleagues who are part of the same IRB-approved protocol, ensuring compliance while fostering cross-disciplinary research. 

Project Overview

My Role

Lead Product Designer

Team

Agile Development Team (5-7 developers), NIH stakeholders, and end-users

Platform

Web Application (React-based; IBM Cognos integration deprecated)

Tools

Visual Studio Code, Sketch

Timeline

~2 years

Goal

Modernize a legacy NIH web application, reduce onboarding friction, decouple reporting from IBM Cognos, and expand accessibility to academic institutions

Transforming a Legacy Platform Through UX-Centered Innovation

Modernizing the Interface While Cultivating a Design-First Culture

  • Migrated a legacy, static UI to a modern, responsive React-based interface.

  • Replaced IBM Cognos reporting UI with native React components to streamline workflows and reduce costs.

  • Lowered the learning curve through intuitive navigation, inline guidance, and progressive disclosure.

  • Introduced Sketch and collaborative prototyping workflows to a developer-led team unfamiliar with UX.

  • Helped establish a shared component library to standardize design and minimize rework.

  • Facilitated regular cross-functional design reviews to align stakeholders and developers around user needs.

My Approach

As the sole designer, I led user interviews, heuristic evaluations, and stakeholder workshops to uncover pain points and opportunities. With no direct access to the original legacy application, I reverse-engineered functionality by observing workflows and discussing usage patterns with active NIH researchers.

BTRIS User Flow Diagram

BTRIS serves as the NIH’s enterprise data repository, and understanding its structure was my first priority. I began by engaging with stakeholders and reviewing some outdated, often unclear diagrams. Through those conversations and materials, I discovered that BTRIS centralizes data from a wide range of source systems. To clarify the system’s architecture and improve alignment, I developed a redesigned diagram that provided a much clearer view of the overall data flow and helped orient me to the process.

Low Fidelity Block Framing for Rapid Validation

To streamline collaboration and reduce visual noise, I developed block-frame wireframes early in the design cycle. These helped to:

  • Drive discussions focused on layout and flow, rather than pixel-level details

  • Rapidly iterate on core workflows like protocol selection and data verification

  • Align technical feasibility with user needs early in the process

BTRIS' Legacy Active Protocol Subject Screen

Block-frame with Annotations of Active Protocol Subject Screen

Hi-Fidelity UI Implementation

After achieving consensus through wireframes, I evolved the designs into high-fidelity mockups with clear visual hierarchy, modern interaction patterns, and BTRIS branding.

Final Hi-Fidelity Active Protocol Subject Screen

Key Workflow Improvements

Note: While login, access, and report generation screens are not detailed in this case study, they followed the same user-centered design approach:

  • Login & Access: Simplified authentication with intuitive guidance for first-time users.

  • Protocol Selection: Reimagined selection flow with real-time filtering and clear confirmation modals.

  • Report Generation: Replaced IBM Cognos with a custom, flexible reporting interface supporting dynamic filters and field selection.

  • Review & Export: Consolidated review and export steps with intuitive formatting and support for PDF and Excel outputs.

Impact

Metric

Improvement

Support Tickets

Estimated reduction of 40-50% due to improved UX clarity

Annual Licensing Costs

$0 (eliminated IBM Cognos dependency)

Onboarding Time for Researchers

Reduced from an estimated 2-3 weeks to under 1 week

System Scalability

Enabled future expansion to academic institutions and non-NIH collaborators

Reflection

The BTRIS project taught me that modernization is as much about trust as it is about technology.The NIH researchers who depended on this system had spent years navigating its quirks. They didn't need a radical overhaul—they needed a partner who respected their expertise while gently guiding them toward something better. My job wasn't just to redesign an interface; it was to earn the trust required to make change feel safe.

What I'm most proud of is the cultural shift that outlasted the code. When I joined, the engineering team viewed design as an afterthought. By the time we launched, they were proactively requesting user feedback and advocating for design reviews. That transformation—from "design is what you do at the end" to "design is how we start"—was more satisfying than any pixel-perfect mockup.

If I were to do this again, I would prototype with real users earlier and more often. Without direct access to the legacy system, I reverse-engineered workflows by observing researchers and asking questions. That worked, but I underestimated how much low-fidelity, clickable prototypes would have accelerated alignment—not just with users, but with stakeholders who needed to visualize the future before they could fund it.

Ultimately, BTRIS reminded me that great design is invisible. When researchers can focus on their science instead of the software, we've done our job.

The BTRIS project taught me that modernization is as much about trust as it is about technology. The NIH researchers who depended on this system had spent years navigating its quirks. They didn't need a radical overhaul—they needed a partner who respected their expertise while gently guiding them toward something better. My job wasn't just to redesign an interface; it was to earn the trust required to make change feel safe.

What I'm most proud of is the cultural shift that outlasted the code. When I joined, the engineering team viewed design as an afterthought. By the time we launched, they were proactively requesting user feedback and advocating for design reviews. That transformation—from "design is what you do at the end" to "design is how we start"—was more satisfying than any pixel-perfect mockup.

If I were to do this again, I would prototype with real users earlier and more often. Without direct access to the legacy system, I reverse-engineered workflows by observing researchers and asking questions. That worked, but I underestimated how much low-fidelity, clickable prototypes would have accelerated alignment—not just with users, but with stakeholders who needed to visualize the future before they could fund it.

Ultimately, BTRIS reminded me that great design is invisible. When researchers can focus on their science instead of the software, we've done our job.

Tim Nicholson © 2026-2027

Tim Nicholson © 2026-2027

Tim Nicholson © 2026-2027

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